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血液病醫院

個人簡介

韋俊博士,1987年生,籍貫福建,國家自然科學基金優秀青年科學基金項目(海外)獲得者,中國醫學科學院血液病醫院(中國醫學科學院血液學研究所)實驗血液學國家重點實驗室研究員,博士生導師。2008年和2013年于南開大學生命科學學院畢業,分別獲得生命科學學士學位和生物化學與分子生物學博士學位。2013年至2021年在美國St. Jude Children's Research Hospital進行博士后研究并先后任職Staff Scientist和Scientific Manager。2021年3月入職血研所任研究員。


主要研究方向

研究方向為T細胞介導的免疫應答與免疫耐受,解析生理及病理狀態下T細胞命運與功能特化的機制,揭示免疫應答及免疫耐受建立和重構的新理論和新策略,為重大疾病的治療提供基礎。研究成果在Nature、Nature Immunology等雜志上發表。


代表性成果

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1. Long L#, Wei J#, Lim SA, Raynor J, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NW, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang Y-D, Li Y, Niu M, Dhungana Y, KC A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. (2021) CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature, 600(7888):308-313

2. Lim SA#, Wei J#, Nguyen TM, Shi H, Su W, Palacios G, Dhungana Y, Chapman NM, Long L, Saravia J, Vogel P, Chi H. (2021) Lipid signalling enforces functional specialization of Treg cells in tumours. Nature, 591(7849):306-311 (Selected by News and Views, Nature, 591(7849):204-206, 2021; F1000 recommended article)

3. Wei J, Zheng W, Chapman NW, Geiger TL, Chi H. (2021) T cell metabolism in homeostasis and cancer immunity. Current Opinion in Biotechnology, 68:240-250. (Invited review)

4. Wei J#, Long L#, Zheng W, Dhungana Y, Lim S, Guy C, Wang Y, Wang Y-D, Qian C, Xu B, KC A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. (2019) Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature, 576(7787):471-476 (Selected by News and Views, Nature, 576(7787):392-393, 2019; Selected by Research Highlights, Nature Reviews Drug Discovery, 19:91, 2020; Selected by Research Highlight, Nature Immunology, 21:103, 2020; F1000 recommended article)

5. Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H. (2016) Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nature Immunology, 17(3):277-85. (Cover Story; Selected by Research Highlights, Nature Reviews Immunology, 16(4):203, 2016)

6. Wei J#, Yang K#, Chi H. (2014) Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision. The Journal of Immunology, 193(9):4297-4301.

7. Xia S#, Wei J#, Wang J, Sun H, Zheng W, Li Y, Sun Y, Zhao H, Zhang S, Wen T, Zhou X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. (2014) A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. Journal of Leukocyte Biology, 95(5):733-742.

8. Wei J#, Xia S#, Sun H, Zhang S, Wang J, Zhao H, Wu X, Chen X, Hao J, Zhou X, Zhu Z, Gao X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. (2013) Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. The Journal of Immunology, 191(1):500-8.

9. Wei J#, Wang H#, Zhu M, Ding D, Li D, Yin Z, Wang L, Yang Z. (2013) Janus nanogels of PEGylated Taxol and PLGA-PEG-PLGA copolymer for cancer therapy. Nanoscale, 5(20):9902-7.

10. Wang H#, Wei J#, Yang C, Zhao H, Li D, Yin Z, Yang Z. (2012) The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol. Biomaterials, 33(24):5848-53.