程輝，中國醫(yī)學(xué)科學(xué)院血液病醫(yī)院（血研所）研究員，協(xié)和準長聘助理教授，博導(dǎo)。2007年獲浙江大學(xué)學(xué)士學(xué)位。2013年獲北京協(xié)和醫(yī)學(xué)院博士學(xué)位。研究方向為造血干細胞及其微環(huán)境。以第一/通訊作者（含共同）在Nat Cell Biol、J Clin Invest、J Exp Med、Blood等雜志上發(fā)表論文和綜述20余篇。國家重點研發(fā)計劃首席科學(xué)家。獲國家優(yōu)青、天津市杰青等人才項目。獲國家自然科學(xué)獎二等獎。獲國內(nèi)外專利5項。中國生理學(xué)會青年委員和天津市血液與再生醫(yī)學(xué)學(xué)會理事。

作為最早被應(yīng)用于臨床的成體干細胞，造血干細胞（HSC）功能和分化模式一直以來是研究的熱點。我們實驗室的研究目標是明確HSC在穩(wěn)態(tài)和疾病狀態(tài)下的內(nèi)外調(diào)控機制，揭示微環(huán)境在其中的變化規(guī)律繼而對HSC的影響機理，探討HSC選擇性保護的分子機制，以期為白血病的治療提供新的思路和策略。

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2. Wang T.#, Xia C.#, Weng Q., Wang K., Dong Y., Hao S., Dong F., Liu X., Liu L., Geng Y., Guan Y., Du J., Cheng T., Cheng H.*, Wang J*. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022; 107(1). (IF=11.047)

3. Wang FJ.#, He J.#, Liu S.#, Gao A., Yang L., Sun G., Ding W., Li C., Wang F., Wang X., Zhu P., Hao S., Ma Y.*, Cheng H.*, Yu J.*, Cheng T*. Comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021;138(20). (IF=25.476)

4. Yuan S., Sun G., Zhang Y., Dong F., Cheng H.*, Cheng T*. Understanding the ‘SMART’ features of hematopoietic stem cells and beyond. Sci China Life Sci. 2021;64(12). (IF=10.372)

5. Huang D.#, Sun G.#, Hao X.#, He X.#, Zheng Z., Chen C., Yu Z., Xie L., Ma S., Liu L., Zhou B., Cheng H.*, Zheng J.*, and Cheng T*. ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021;131(1). (IF=19.456)

6. Zhang C.#, Xu Z.#, Yang S.#, Sun G.#, Jia L., Zheng Z., Gu Q., Tao W.*, Cheng T.*, Li C.* and Cheng H.*. tagHi-C reveals 3D chromatin architecture dynamics during hematopoiesis. Cell Rep. 2020;32(13). (IF=9.423)

7.   Dong F., Cheng H.*, Ema H.*, Cheng T*. Probing the fate of transplanted hematopoietic stem cells: is the combinational approach "FIT" for purpose? Sci China Life Sci. 2020;63(11):1755-8. (IF=6.037)

8.   Dong F.#, Hao S.#, Zhang S.#, Zhu C.#, Cheng H.#, et al. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020;22(6):630-9. (IF=28.824)

9.   Xia C.#, Wang T.#, Cheng H.#, et al. Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 2020;34(9):2375-83. (IF=11.528)

10. Ma S.#, Sun G.#, Yang S., Ju Z.*, Cheng T.*, Cheng H.*. Effects of telomere length on leukemogenesis. Sci China Life Sci. 2020;63(2):308-11. (IF=6.037)