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生物醫學工程研究所

個人簡介

梅林,1982年出生,江西吉安人,生物材料和藥劑學家,中國醫學科學院生物醫學工程研究所研究員,博士生導師。1999年考入復旦大學藥學專業,2003年獲得學士學位。2003年在北京協和醫學院生物醫學工程專業攻讀博士學位,從事生物醫學材料和藥物控釋研究。之后分別在新加坡國立大學和清華大學進行博士后研究,主要從事納米醫學和藥物載體系統研究。2010年任清華大學深圳國際研究生院副教授。2017年任中山大學“百人計劃”教授、博導。


主要研究方向

以臨床問題為導向,醫工交叉融合,主要從事生物醫學材料、納米醫學、疫苗遞送、藥物載體系統和分子藥劑學研究。


代表性成果

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1. Lin YX#, Wang Y#, Ding JX, Jiang AP, Wang J, Yu M, Blake S, Liu SS, Bieberich CJ, Farokhzad OC*, Mei L*, Wang H*, Shi JJ*. Tumor suppressor reactivation by mRNA nanoparticles induces anti-tumor immunity and improves immune checkpoint blockade therapy. Science Translational Medicine. 2021;599(13):eaba9772. (IF=17.956, F1000)

2. Ou M, Lin C, Wang Y, Lu Y, Wang W, Li Z, Zeng W, Zeng X, Ji X*, Mei L*. Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy. Journal of Controlled Release. 2022;345:755-769. (IF=11.467)

3. Yu M#, Yu J#, Yi Y, Chen T, Yu L, Zeng W, Ouyang XK, Huang C, Sun S, Wang Y, Liu Y, Lin C, Wu M*, Mei L*. Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy. Journal of Controlled Release. 2022;347:104-114. (IF=11.467)

4. Zeng W#, Yu M#, Chen T#, Liu Y, Yi Y, Huang C, Tang J, Li H, Ou M, Wang T, Wu M*, Mei L*. Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy. Advanced Science. 2022:e2201703. (IF=17.521)

5. Zhang H#, Zeng W#, Pan C#, Feng L, Ou M, Zeng X, Liang X, Wu M, Ji X*, Mei L*. SnTe@MnO2‐SP Nanosheet–Based Intelligent Nanoplatform for Second Near‐Infrared Light–Mediated Cancer Theranostics. Advanced Functional Materials. 2019;29(37):1903791. (IF=15.621, C100)

6. Ye X#, Liang X#, Chen Q, Miao Q, Chen X, Zhang X*, Mei L*. Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy. ACS Nano. 2019;13(3):2956-2968. (IF=13.903, ESI, C100)

7. Zeng X#, Luo M#, Liu G, Wang XS, Tao W, Lin Y, Ji XY, Nie L, Mei L*. Polydopamine-modified black phosphorous nanocapsule with enhanced stability and photothermal performance for tumor multimodal treatments. Advanced Science. 2018;5(10):1800510. (IF=12.441, ESI, C100)

8. Tao W#, Zhu X#, Yu X#, Zeng X, Xiao Q, Zhang X, Ji X, Wang X, Shi J*, Zhang H*, Mei L*. Black phosphorus nanosheets as a robust delivery platform for cancer theranostics. Advanced Materials. 2017;29 (1):1603276. (IF=19.791, ESI, C100)

9. Cheng W, Nie J, Gao N, Liu G*, Tao W, Xiao X, Jiang L, Liu Z, Zeng X*, Mei L*. A multifunctional nanoplatform against multidrug resistant cancer: merging the best of targeted chemo/gene/photothermal therapy. Advanced Functional Materials. 2017;27(45):170413. (IF=12.124, C100)

10. Chen T, Zeng WW, Tie CJ, Yu M, Hao HS, Deng Y, Li QQ, Zheng HR*, Wu MY*, Mei L*. Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics. Bioactive Materials. 2022;10:515-525. (IF=16.874)